Product name : CAPN2 Antibody
Catalog number : CSB-PA004496LB01HU_100ug
Supplier : Cusabio
Price : 302 EUR
Size : 100ug
Alias : Calpain M-type,Calpain large polypeptide L2,Calpain-2 large subunit,Millimolar-calpain,CAPN2,CANPL2
Antibody category : Polyclonal Antibodies
Background : Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Buffer composition : Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Classification : Calpains EF-hand domain containing
Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Conjugation : HRP
Discovery year : 1989-06-30
Entrez Gene : calpain 2 (CAPN8)
Entrez gene record : 824
GenBank acession : J04700
Gene : CAPN2
Gene ontology - Biological process : response to hypoxia proteolysis extracellular matrix disassembly proteolysis involved in cellular protein catabolic process cellular response to amino acid stimulus myoblast fusion regulation of cytoskeleton organization protein autoprocessing blastocyst development
Gene ontology - Cellular component : nucleus cytoplasm cytosol extracellular exosome endoplasmic reticulum Golgi apparatus membrane raft dendrite perinuclear endoplasmic reticulum cortical actin cytoskeleton
Gene ontology - Molecular function : protein binding calcium-dependent cysteine-type endopeptidase activity calcium ion binding protein heterodimerization activity cysteine-type peptidase activity cytoskeletal protein binding
Havana BLAST/BLAT : OTTHUMG00000037376
Identity : 1479
Immunogen species : Human
Immunogen type : Recombinant human Calpain-2 catalytic subunit protein (20-700AA)
InterPro : Peptidase C2, calpain, domain III (CPLX3) EF-Hand 1, calcium-binding site (TSFM) EF-hand domain pair (TSFM) Peptidase C2, calpain, catalytic domain Cysteine peptidase, cysteine active site Peptidase C2, calpain family Peptidase C2, calpain, large subunit, domain III (CPLX3) EF-hand domain (EFHD1) (EFHD2) (TSFM) Calpain-2 (CAPN8)
Kegg : Alzheimer,s disease - Homo sapiens (human) Apoptosis - Homo sapiens (human) Focal adhesion - Homo sapiens (human) Protein processing in endoplasmic reticulum - Homo sapiens (human)
Locus : 1q41
Long gene name : calpain 2
Long name : Rabbit Antibody against Human CAPN2, HRP
Name : Blotting, Western
PubMed : Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) The hGAAP is a novel regulator of focal adhesion dynamics, cell adhesion, and migration by controlling localized Ca(2 )-dependent activation of calpain. m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions. cleavage of CPEB3 by NMDA-activated calpain 2 accounts for the activity-related translation of CPEB3-targeted RNAs ionomycin-induced calpain activation promotes decrease of Bcl-2 proteins thereby triggering the intrinsic apoptotic pathway cancer invasiveness is independent of intracellular calpain 2 proteolytic activity that is usually needed for turnover of integrin-linked adhesions during two-dimensional planar migration both calpain 1 and calpain 2 are essential for the replication of EV1 RNA. These results not only identify calpain-2 as a substrate for sumoylation but also provide an important role of sumoylation in regulating cell migration. The calcium-calpain-caspase-12-caspase-3 cascade is altered in F508del-CFTR expressing cells. Data show that transfection of cells with GRP78 or calpain I and calpain II siRNA reduced MPTB-mediated cell apoptosis in chondrosarcoma JJ012 cells.
Pubmed identfication : 2852952 2539381
Purification method : Protein G purified
Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
RefSeq identity : NM_001748
Species reactivity : Human
Synonym name : CAPN2 Human Antibody
Synonyms : mCANP CANPml CANPL2
Synonyms gene name : calpain 2, (m/II) large subunit
Tested applications & recommended dilutions : ELISA
Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200
UniProt ID : P17655
WikiPathWays : VEGFA-VEGFR2 Signaling Pathway Alzheimers Disease Integrin-mediated Cell Adhesion
